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Clinical Overview of Group B Strep Disease
Cause
Streptococcus agalactiae or GBS cause GBS disease.
Risk factors
Pregnancy related risk factors
The following groups are at increased risk for GBS disease:
- Pregnant and postpartum women
- Fetuses
- Neonates
For neonatal disease, risk is higher among infants born to women with
- GBS colonization
- Prolonged rupture of membranes
- Preterm delivery
Other factors
Other factors that can increase adults' risk of GBS disease include:
- Age
- Medical conditions
- Race
Age
Risk increases with age: Adults 65 years or older are at increased risk compared to adults younger than 65 years old.
Medical conditions
Medical conditions that can increase adults' risk include:
- Cancer
- Cardiovascular disease
- Diabetes mellitus
- Obesity
Race
Experts do not know why, but disease rates are also substantially higher among African American people.
How it spreads
Asymptomatic carriage in gastrointestinal and genital tracts is common.
Intrapartum transmission via ascending spread from the vagina occurs. Mode of transmission of disease
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